​2023

  • Millar, D. G., Yang, S. Y. C., Sayad, A., Zhao, Q., Nguyen, L. T., Warner, K., Sangster, A. G., Nakatsugawa, M., Murata, K., Wang, B. X., Shaw, P., Clarke, B., Bernardini, M. Q., Pugh, T., Thibault, P., Hirano, N., Perreault, C., & Ohashi, P. S. (2023). Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire. Cancer Immunology, Immunotherapy: CII. doi:10.1007/s00262-023-03413-7.
  • Mlecnik, B., Lugli, A., Bindea, G., Marliot, F., Bifulco, C., Lee, J.-K. J., Zlobec, I., Rau, T. T., Berger, M. D., Nagtegaal, I. D., Vink-Börger, E., Hartmann, A., Geppert, C. I., Kolwelter, J., Merkel, S., Grützmann, R., Van den Eynde, M., Jouret-Mourin, A., Kartheuser, A., … , Ohashi, P., Nguyen, L., Han, S., ... Galon, J. (2023). Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer. Cancers. 15(2):418. doi:10.3390/cancers15020418.

2022

  • Mlecnik, B., Torigoe, T., Bindea, G., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Hirohashi, Y., Furuhata, T., Takemasa, I., Patel, P., Vora, H., Shah, B., Patel, J. B., Rajvik, K. N., Pandya, S. J., … Galon, J. (2022). Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Cancers. 14(18):4346. doi:10.3390/cancers14184346.
  • Warner, K., Ghaedi, M., Chung, D. C., Jacquelot, N., Ohashi, P. S. (2022). Innate lymphoid cells in early tumor development. Frontiers in Immunology. 13. doi:10.3389/fimmu.2022.948358.
  • Boukhaled, G. M., Gadalla, R., Elsaesser, H. J., Abd-Rabbo, D., Quevedo, R., Yang, S. Y. C., Guo, M., Wang, B. X., Noamani, B., Gray, D., Lau, S. C. M., Taylor, K., Aung, K., Spreafico, A., Hansen, A. R., Saibil, S. D., Hirano, N., Guidos, C., Pugh, T. J., … Brooks, D. G. (2022). Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy. Nature Immunology. 23(8):1273–1283. doi:10.1038/s41590-022-01262-7.
  • Nguyen, L.T., Lo, C.S., Fyrsta, M., Nie, J., Yam, JY., Yen, PH., Le, M.X., Hersey, K., Kenk, M., Crumbaker, M., Fleshner, N., Kulkarni, G., Hamilton, R., Jewett, M., Finelli, A., Evans, A., Sweet, J., Ohashi, P.S., and Joshua, A.M. (2022). Expansion of Lymphocytes from Prostatic Adenocarcinoma and Adjacent Nonmalignant Tissue. Prostate Cancer. 2022:e6499344. doi: 10.1155/2022/6499344.
  • Dimitriou, I. D., Meiri, D., Jitkova, Y., Elford, A. R., Koritzinsky, M., Schimmer, A. D., Ohashi, P. S., Sonenberg, N., Rottapel, R. (2022). Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation. Journal of Immunology (Baltimore, Md.: 1950). 208(12):2702–2712. doi:10.4049/jimmunol.2101090.
  • Chung, D. C., Jacquelot, N., Ghaedi, M., Warner, K., Ohashi, P. S. (2022). Innate Lymphoid Cells: Role in Immune Regulation and Cancer. Cancers. 14(9):Article 9. doi:10.3390/cancers14092071.
  • Lin, C.-C., Chang, T.-Y., Lu, Y.-C., Wu, Y.-S., Huang, W., Lo, W.-C., Liu, G.-F., Hsu, W.-C., Ohashi, P. S., Mak, T. W., Fuh, J.-L., Chen, H.-C., Tarng, D.-C., Chen, N.-J. (2022). TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases. Journal of Molecular Medicine (Berlin, Germany). 100(6):917–931. doi:10.1007/s00109-022-02201-7.
  • Brooks, D. G., Ohashi, P. S. (2022). DC1s shield Tpex cells to bolster PD-1 blockade. Immunity. 55(4):577–579. doi: 10.1016/j.immuni.2022.03.017.​
  • Lheureux, S., Matei, D. E., Konstantinopoulos, P. A., Wang, B. X., Gadalla, R., Block, M. S., Jewell, A., Gaillard, S. L., McHale, M., McCourt, C., Temkin, S., Girda, E., Backes, F. J., Werner, T. L., Duska, L., Kehoe, S., Colombo, I., Wang, L., Li, X., … Fleming, G. F. (2022). Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer. Journal for Immunotherapy of Cancer. 10(3):e004233.doi:10.1136/jitc-2021-00423.
  • Han, S., Liu, Z. Q., Chung, D. C., Paul, M. S., Garcia-Batres, C. R., Sayad, A., Elford, A. R., Gold, M. J., Grimshaw, N., Ohashi, P. S. (2022). Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity. Cancer Immunology Research. 10(4):437–452. doi:10.1158/2326-6066.CIR-20-0973.
  • Cheung, A. M., Wang, D., Liu, K., Hynes, S., Wang, B., Stone, S., Ohashi, P.S., Yaffe, M. J. (2022). Spatial analysis of cellular arrangement using quantitative, single-cell imaging of protein multiplexing. Medical Imaging 2022: Digital and Computational Pathology. 12039:127–133. doi:10.1117/12.2610955.
  • Hezaveh, K., Shinde, R. S., Klötgen, A., Halaby, M. J., Lamorte, S., Ciudad, M. T., Quevedo, R., Neufeld, L., Liu, Z. Q., Jin, R., Grünwald, B. T., Foerster, E. G., Chaharlangi, D., Guo, M., Makhijani, P., Zhang, X., Pugh, T. J., Pinto, D. M., Co, I. L., … McGaha, T. L. (2022). Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity. Immunity. 55(2):324-340.e8. doi:10.1016/j.immuni.2022.01.006.
  • Das, A., Sudhaman, S., Morgenstern, D., Coblentz, A., Chung, J., Stone, S. C., Alsafwani, N., Liu, Z. A., Karsaneh, O. A. A., Soleimani, S., Ladany, H., Chen, D., Zatzman, M., Cabric, V., Nobre, L., Bianchi, V., Edwards, M., Sambira Nahum, L. C., Ercan, A. B., … Tabori, U. (2022). Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency. Nature Medicine. 28(1):125–135. doi:10.1038/s41591-021-01581-6.

2021

  • Jacquelot, N., Ghaedi, M., Warner, K., Chung, D. C., Crome, S. Q., Ohashi, P. S. (2021). Immune Checkpoints and Innate Lymphoid Cells-New Avenues for Cancer Immunotherapy. Cancers. 13(23):5967. doi:10.3390/cancers13235967.
  • St Paul, M., Saibil, S. D., Han, S., Israni-Winger, K., Lien, S. C., Laister, R. C., Sayad, A., Penny, S., Amaria, R. N., Haydu, L. E., Garcia-Batres, C. R., Kates, M., Mulder, D. T., Robert-Tissot, C., Gold, M. J., Tran, C. W., Elford, A. R., Nguyen, L. T., Pugh, T. J., … Ohashi, P. S. (2021). Coenzyme A fuels T cell anti-tumor immunity. Cell Metabolism. 33(12):2415-2427.e6. doi:10.1016/j.cmet.2021.11.010.
  • Jaiswal, A., Murakami, K., Elia, A., Shibahara, Y., Done, S. J., Wood, S. A., Donato, N. J., Ohashi, P. S., Reedijk, M. (2021). Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 118(38):e2101592118. doi:10.1073/pnas.2101592118.
  • Cindy Yang, S. Y., Lien, S. C., Wang, B. X., Clouthier, D. L., Hanna, Y., Cirlan, I., Zhu, K., Bruce, J. P., El Ghamrasni, S., Iafolla, M. A. J., Oliva, M., Hansen, A. R., Spreafico, A., Bedard, P. L., Lheureux, S., Razak, A., Speers, V., Berman, H. K., Aleshin, A., … Pugh, T. J. (2021). Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity. Nature Communications. 12(1):5137. doi:10.1038/s41467-021-25432-7.
  • Jacquelot, N., Seillet, C., Souza-Fonseca-Guimaraes, F., Sacher, A. G., Belz, G. T., Ohashi, P. S. (2021). Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives. International Journal of Molecular Sciences. 22(16):9044. doi:10.3390/ijms22169044.
  • Ohashi, P.S., Sharpe, A. (2021). Editorial overview: Cancer Immunotherapy:Are we there yet? Curr Opin Immunol. 69:iii-v. doi: 10.1016/j.coi.2021.04.008.
  • Campbell, B., Galati, M., Stone, S., Riemenschneider, A., Edwards, M., Sudhaman, S., Siddaway, R., Komosa, M., Nunes, N., Nobre, L., Morrissy, A.S., Zatzman, M., Zapotocky, M., Joksimovic, L., Kalimuthu, S., Samuel, D., Mason, G., Bouffet, E., Morgenstern, D., Aronson, M., Durno, C., Malkin, D., Maris, J., Taylor, M., Shlien, A., Pugh, T.J., Ohashi, P.S., Hawkins, C., Tabori, U. (2021). Mutations in the RAS/MAPK pathway drive replication repair deficient hypermutated tumors and confer sensitivity to MEK inhibition. Cancer Discov. Doi: 10.1158/2159-8290.
  • Chakraborty, M., Chu, K., Shrestha, A., Revelo, X.S., Zhang, X., Gold, M.J., Khan, S., Lee, M., Huang, C., Akbari, M., Barrow, F., Chan, Y.T., Lei, H., Kotoulas, N.K., Jovel, J., Pastrello, C., Kotlyar, M., Goh, C., Michelakis, E., Clemente-Casares, X., Ohashi, P.S., Engleman,E.G., Winer, S., Jurisica, I., Tsai, S., Winer, D.A. (2021). Mechanical Stiffness Controls Dendritic Cell Metabolism and Function. Cell Reports. 34(2):108609.

2020

  • Han, S., Chung, DC., St. Paul, M., Liu, ZQ., Garcia-Batres, C., Elford, AE., Tran, CW., Chapette, L., Ohashi, PS. (2020). Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cells. OncoImmunology. 9(1):e1737368.
  • St Paul, M., Saibil, SD., Lien, SC., Han, S., Sayad, A., Mulder, DT., Garcia-Batres, CR., Elford, AR., Israni-Winger, K., Robert-Tissot, C., Zon, M., Katz, SR., Shaw, PA., Clarke, BA., Bernardini, MQ., Nguyen, LT., Haibe-Kains, B., Pugh, TJ., Ohashi, PS. (2020). IL6 Induces an IL22+ CD8+ T-cell Subset with Potent Antitumor Function. Cancer Immunology Research. 8(3):321-333.
  • Tran, C.W. , Gold, MJ, Garcia-Batres, C., Tai, K., Elford, AR., Himmel, M.E., Elia, AJ., Ohashi, P.S. (2020). Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity. PLoS ONE. 15(12):e0244366.
  • Lang, PA., Crome, SQ., Xu, HC., Lang, KS., Chapatte, L., Deenick, EK., Grusdat, M., Pandyra, AA., Pozdeev, VI., Wang, R., Holderried, TAW., Cantor, H., Diefenbach, A., Elford, AR., McIlwain, DR., Recher, M., Häussinger, D., Mak, TW., Ohashi, PS. (2020). NK Cells Regulate CD8+ T Cell Mediated Autoimmunity. Frontiers in Cellular and Infection Microbiology. 10:36. doi: 10.3389/fcimb.2020.00036.
  • St. Paul, M., Ohashi, P.S. (2020). The roles of CD8+ T cell subsets in antitumor immunity. Trends Cell Biol. (9):695-704.
  • Ghaedi, M., Ohashi, P.S. (2020). ILC transdifferentiation: roles in cancer progression. Cell Research. 30:562-563.
  • Saibil, S.D., Ohashi, P.S. (2020). Targeting T cell activation in Immuno-oncology. Current Oncology. Suppl2:S98—S105.
  • Sacher, A.G., St. Paul, M., Paige, C.J., Ohashi, P.S. (2020). Cytotoxic CD4+ T cells in bladder cancer-A new license to kill. Cancer Cell. 38(1):28-30.
  • Mlecnik, B., Bifulco, C., Bindea, G., Marliot, F., Lugli, A., Ou, F-S., Zlobec, I., Rau, T.T., Berger, M.D., Nagtegaal, ID, Vink-Börger, E., Hartmann, A., Geppert, C., Kolwelter, J. ... Ohashi, P.S., Nguyen, L.T., Han, S., MacGregor, H.L., ... Ascierto, P.A., Fox, B.A., Pagès, F., Galon, J. (2020). Multicenter international SITC study of the consensus immunoscore for the prediction of survival and response to chemotherapy in Stage III colon cancer. J Clin Oncol. 38(31):3638-3651.
  • Bratman, S., Yang, S.Y., Iafolla, M., Liu, Z.A., Hansen, A.R., Bedard, P.L., Lheureux, S., Spreafico, A., Razak, A.A.R., Shchegrova, S., Louie, M., Billings, P., Zimmerman, B., Sethi, H., Aleshin, A., Torti, D., Marsh, K., Eagles, J., Cirlan, I., Hanna, Y., Clouthier, D., Lien, S.C., Ohashi, P.S., Xu, W., Siu, L.L. and Pugh, T.J. (2020). Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab. Nature Cancer. (1)873-881.
  • Taylor, K., Loo Yau, H., Chakravarthy, A., Wang, B.X., Yi Shen, S., Ettayebi I., Ishak, C.A., Bedard, P.L., Razak, A.A.R., Hansen, A.R., Spreafico, A., Cescon, D.W., Butler, M.O., Oza, A.M., Lheureux, S., Stjepanovic, N., Van As, B., Boross-Harmer, S., Wang, L., Pugh, T.J., Ohashi, P.S., Siu, L.L., De Carvalho, D.D. (2020). An open-label, phase II multicohort study of an oral hypomethylating agend CC-486 and durvalumab in advanced solid tumors. Journal for ImmunoTherapy of Cancer. 8(2):e000883.
  • Murata, K., Nakatsugawa, M., Rahman, MA., Nguyen, L., Millar, DG., Mulder, DT., Sugata, K., Saijo, H., Matsunaga, Y., Kagoya, Y., Guo, T., Anczurowski, M., Wang, CH., Burt, BD., Saso, K., Easson, A., Goldstein, DP., Reedijk, M., Ghazarian, DA., Pugh, TJ., Butler, MO., Mak, TW., Ohashi, P.S., Hirano, N. (2020). Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. Elife. 9:e53244.
  • Zhao, Q., Laverdure, JP., Lanoix, J., Durette, C., Côté, C., Bonneil, É., Laumont, CM., Gendron, P., Vincent, K., Courcelles, M., Lemieux, S., Millar, DG., Ohashi, PS., Thibault, P., Perreault, C. (2020). Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer. Cancer Immunology Research. 8(4):544-555.
  • Romero, J.M., Grunwald, B., Jang, G-H., Bavi, P., Jhaveri, A., Masoomian, M., Fischer, S., Zhang, A., Denroche, R., Lungu, I., De Luca, A., Bartlett, J., Xu, J., Li, N., Dhaliwal, S., Liang, SB., Chadwick, D., Vyas, F., Bronsert, P., Khokha, R., McGaha, T., Notta, F.,
    Ohashi, P.S., Done, S., O’Kane, G., Wilson, J., Knox, J., Connor, A., Wang, Y., Zogopoulos, G., and Gallinger, S. (2020). A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer. Clin Cancer
    Res    . 26(8):1997-2010.

2019
  • Han, S. Toker, A. Liu, ZQ. Ohashi, PS. (2019). Turning the tide against regulatory T cells. Frontiers in Oncology. 9(279):1-16.
  • MacGregor, HL. Sayad, A. Elia, A. Wang, BX. Katz, SR. Shaw, PA. Clarke, BA. Crome, SQ. Robert-Tissot, C. Bernardini, MQ. Nguyen, LT. Ohashi, PS. (2019). High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation. Journal for Immunotherapy of Cancer. 7(1):357.
  • Halaby, MJ. Hezaveh, K. Lamorte, S. Ciudad, MT. Kloetgen, A. MacLeod, BL. Guo, M. Chakravarthy, A. Medina, TDS. Ugel, S. Tsirigos, A. Bronte, V. Munn, DH. Pugh, TJ. De Carvalho, DD. Butler, MO. Ohashi, PS. Brooks, DG. McGaha, TL. (2019). GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment. Science Immunology. 4(42). pii: eaax8189.
  • MacGregor, HL. Garcia-Batres, C. Sayad, A. Elia, A. Berman, HK. Toker, A. Katz, SR. Shaw, PA. Clarke, BA. Crome, SQ. Robert-Tissot, C. Bernardini, MQ. Nguyen, LT. Ohashi, PS. (2019). Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer. Oncolmmunology. 8(12):e1665460.
  • Martin, K. Touil, R. Kolb, Y. Cvijetic, G. Murakami, K. Israel, L. Duraes, F. Buffet, D. Glück, A. Niwa, S. Bigaud, M. Junt, T. Zamurovic, N. Smith, P. McCoy, KD. Ohashi, PS. Bornancin, F. Calzascia, T. (2019). Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity. Journal of Immunology. 203(11):2791-2806.
  • Dafni, U. Michielin, O. Lluesma, SM. Tsourti, Z. Polydoropoulou, V. Karlis, D. Besser, MJ. Haanen, J. Svane, IM. Ohashi, PS. Kammula, US. Orcurto, A. Zimmermann, S. Trueb, L. Klebanoff, CA. Lotze, MT. Kandalaft, LE. Coukos, G. (2019). Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis. Annals of Oncology. 30(12):1902-1913.
  • Warner, K. Ohashi, PS. (2019). ILC regulation of T cell responses in inflammatory diseases and cancer. Seminars in Immunology. 41:101284.
  • Toker, A. Ohashi, PS. (2019). Expression of costimulatory and inhibitory receptors in FoxP3+ regulatory T cells within the tumor microenvironment: Implications for combination immunotherapy approaches. Advances in Cancer Research. 144:193-261.
  • Gadalla, R. Noamani, B. MacLeod, BL. Dickson, RJ. Guo, M. Xu, W. Lukhele, S. Elsaesser, HJ. Razak, ARA. Hirano, N. McGaha, TL. Wang, B. Butler, M. Guidos, CJ. Ohashi, PS. Siu, LL. Brooks, DG. (2019). Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials. Frontiers in Oncology. 9:415.
  • Jiang, DM. Fyles, A. Nguyen, LT. Neel, BG. Sacher, A. Rottapel, R. Wang, BX. Ohashi, PS. Sridhar, SS. (2019). Phase I study of local radiation and tremelimumab in patients with inoperable locally recurrent or metastatic breast cancer. Oncotarget. 10(31):2947-2958.
  • Clouthier, DL. Lien, SC. Yang, SYC. Nguyen, LT. Manem, VSK. Gray, D. Ryczko, M. Razak, ARA. Lewin, J. Lheureux, S. Colombo, I. Bedard, PL. Cescon, D. Spreafico, A. Butler, MO. Hansen, AR. Jang, RW. Ghai, S. Weinreb, I. Sotov, V. Gadalla, R. Noamani, B. Guo, M. Elston, S. Giesler, A. Hakgor, S. Jiang, H. McGaha, T. Brooks, DG. Haibe-Kains B. Pugh, TJ. Ohashi, PS. Siu, LL. (2019). An interim report on the investigator-initiated phase 2 study of Pembrolizumab immunological response evaluation (INSPIRE). Journal for Immunotherapy of Cancer. doi: 10.1186/s40425-019-0541-0.
  • Nguyen, LT. Saibil SD. Sotov, V. Le, MX. Khoja, L. Ghazarian, D. Bonilla, L. Majeed, H. Hogg, D. Joshua, AM. Crump, M. Franke, N. Spreafico, A. Hansen, A. Al-Habeeb, A. Leong, W. Easson, A. Reedjik, M. Goldstein, DP. McCready, D. Yasufuku, K. Waddell, T. Cypel, M. Pierre, A. Zhang, B. Boross-Harmer, S. Cipolione, J. Nelles, M. Scheid, E. Fyrsta, M. Lo, CS. Nie, J. Yam, JY. Gray, D. Motta, V. Elford, AR. DeLuca, S. Wang, L. Effendi, S. Ellenchery, R. Hirano, N. Ohashi, PS. Butler, MO. (2019). Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2. Cancer Immunology, Immunotherapy. doi: 10.1007/s00262-019-02307-x.
  • Cox, MA. Duncan, GS. Lin, GHY. Steinberg, BE. Yu, LX. Brenner, D. Buckler, LN. Elia, AJ. Wakeham, AC. Nieman, B. Dominguez-Brauer, C. Elford, AR. Gill, KT. Kubli, SP. Haight, J. Berger, T. Ohashi, PS. Tracy, KJ. Olofsson, PS. Mak, TW. (2019). Choline acetyltransferase-expressing T cells are required to control chronic viral infection. Science. 363(6427):639-644.
  • Benveniste, PM. Nakatsugawa, M. Nguyen, L. Ohashi, PS. Hirano, N. Zuniga-Pflucker, JC. (2019). In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naive timor-infiltrating lymphocytes. Immunology & Cell Biology. doi: 10.1111/imcb.12231.
  • Saibil, SD. St Paul, M. Laister, RC. Garcia-Batres, CR. Israni-Winger, K. Elford, AR. Grimshaw, N. Robert-Tissot, C. Roy, DG. Jones, RG. Nguyen, LT. Ohashi, PS. (2019). Activation of Peroxisome Proliferator-Activated Receptors α and δ synergizes with inflammatory signals to enhance adoptive cell therapy.  Cancer Research. 79(3):445-451.

2018

  • Benveniste, PM. Roy, S. Nakatsugawa, M. Chen, ELY. Nguyen, L. Millar, DG. Ohashi, PS. Hirano, N. Adams, EJ. Zuniga-Pflucker, JC. (2018). Generation and molecular recognition of melanoma-associated antigen-specific human gamma-delta T cells. Science Immunology. 3(30): eaav4036.
  • Mulder, DT. Mahe, ER. Dowar, M. Hanna, Y. Li, T. Nguyen, LT. Butler, MO. Hirano, N. Delabie, J. Ohashi, PS. Pugh, TJ. (2018). CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling. Blood Advances 2(23):3506-3514.
  • Crome, SQ. Ohashi, PS. (2018). Immunoregulatory functions if innate lymphoid cells. J Immunotherapy Cancer 6(1):121.
  • Yang, SYC. Heureux, S. Karakasis, K. Burnier, JV. Bruce, JP. Cloutheir, DL. Danesh, A. Quevedo, R. Dowar, M. Hanna, Y. Li, T. Lu, L. Zu, W. Clark, BA. Ohashi, PS. Shaw, PA. Pugh, TJ. Oza, AM. (2018). Landscape of genomic alterations in high-grad serous ovarian cancer from exceptional long-and short-term survivors. Genome Med. 10(1):81.
  • Dimitriou, ID. Lee, K. Akpan, I. Lind, EF. Barr, VA. Ohashi, PS. Samelson, LE. Rottapel, R. (2018). Timed Regulation of 3BP2 Induction is Critical for Sustaining CD8+ T Cell Expansion and Differentiation. Cell Report 24(5):1123-1135.
  • Toker, A. Nguyen, LT. Stone, SC. Yang, C. Katz, SR. Shaw, PA. Clarke, BA. Ghazarian, DA. Al Habeeb, AS. Easson, AM. Leong, W. McCready, D. Reedijk, M. Guidos, CJ. Pugh, TJ. Bernardini, MQ. Ohashi, PS. (2018). Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma. Clin Cancer Res. doi: 10.1158/1078-0432.CCR-18-0554.
  • Stapleton, S. Dunne, M. Milosevic, M. Tran, CW. Gold, MJ. Vedadi, A. Mckee, TD. Ohashi, PS. Allen, C. Jaffray, DA. (2018). Radiation and Heat Improves the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics. ACS Nano. doi: 10.1021/acsnano.7b06301.
  • Pagès, F. Mlecnik, B. Marliot, F. Bindea, G. Ou, FS. Bifulco, C. ... Ohashi, PS. Nguyen, LT. Han, S. MacGregor, H. ... Galon, J. (2018). International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. The Lancet 391(10135):2128-2139.
  • Iafolla, MAJ. Selby, H. Warner, K. Ohashi, PS. Haibe-Kains, B. Siu, LL. (2018). Rational design and identification of immuno-oncology drug combinations. European Journal of Cancer 95:38-51.

2017

  • ​Tran, CW. Saibil, SD,.Le Bihan, T. Hamilton, SR. Lang, KS. You, H. Lin, AE. Garza, KM,.Elford, AR. Tai, K. Parsons, ME. Wigmore, K. Vainberg, MG. Penninger, JM. Woodgett, JR. Mak, TW. Ohashi, PS. (2017). Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of Immunology 199(12):4056-4065.
  • Shen, Q. Cohen, B. Zheng, W. Rahbar, R. Martin, B. Murakami, K. Lamorte, S. Thompson, P. Berman, H. Zuniga-Pflucker, JC. Ohashi, PS. Reedijk M. (2017). Notch Shapes the Innate Immunophenotype in Breast Cancer. Cancer Discovery 7(11):1320-1335.
  • Lheureux, S. Denoyelle, C. Ohashi, PS. De Bono, JS. Mottaghy, FM. (2017). Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician. Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-017-3695-3.
  • Clouthier, DL. Ohashi, PS. (2017). Costimulation, a surprising connection for immunotherapy. Science 355(6332):1373-1374
  • MacGregor, HL. Ohashi, PS. (2017). Molecular pathways: Evaluating the potential for B7-H4 as an immunoregulatory target. Clin Cancer Res. 23(12):2934-2941.
  • Ono, N. Murakami, K. Chan, O. Hall, H. Elford, AR. Yen, P. Calzascia, T. Spencer, DM. Ohashi, PS. Dhanji, S. (2017). Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes. PLoS One 12(3):e0173176
  • ​Crome, SQ. Nguyen, LT. Lopez-Verges, S. Yang, SY. Martin, B. Yam, JY. Johnson, DJ. Nie, J. Pniak, M. Yen, PH. Milea, A. Sowamber, R. Katz, SR. Bernardini, MQ. Clarke, BA. Shaw, PA. Lang, PA. Berman, HK. Pugh, TJ. Lanier, LL. Ohashi, PS. (2017). A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat. Med. 23(3):368-375.
  • Hao, Z. Sheng, Y. Duncan, GS. Li, WY. Dominguez, C. Sylvester, J. Su, YW. Lin, GH. Snow, BE. Brenner, D. You-Ten, A. Haight, J. Inoue, S. Wakeham, A. Elford, A. Hamilton, S. Liang, Y. Zuniga-Pflucker, JC. He, HH. Ohashi, PS. Mak, TW. (2017). K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nat. Commun. 8:14003.

2016

  • Zheng, W. Umitsu, M. Jagan, I. Tran, CW. Ishiyama, N. BeGora, M. Araki, K. Ohashi, PS. Ikura, M. Muthuswamy, SK. (2016). An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.  Nat. Cell. Biol. 18(11):1244-1252.
  • Maney, SK. Xu, HC. Huang, J. Pandyra, AA. Ehlting, C. Aguilar-Valenzuela, R. Pozdeev, VI. McIlwain, DR. Zimmermann, A. Bode, JG. Hengel, H. Kirschning, CJ. Kim, IR. Hiscott, J. Brenner, D. Häussinger, D. Ohashi, PS. Mak, TW. Lang, KS. Lang, PA. (2016). RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production. Cell. Physiol. Biochem. 39:1271-80.
  • Ohashi, PS. (2016). Zeroing in on Tumor-Reactive TILs. Cancer Immunol. Res. 4:719.
  • Kaufman, HL. Butterfield, LH. Coulie, PG. Demaria, S. Ferris, RL. Galon, J. Khleif, SN. Mellman, I. Ohashi, PS. Overwijk, WW. Topalian, SL. Marincola, FM. (2016). Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule. J Immunother Cancer 4:37.
  • Rahbar, R. Ohashi, PS. (2016). B7-H4 is a positive regulator of antitumor immunity. Oncoimmunology 5:e1050575.
  • Millar, DG. Ohashi, PS. (2016). Central tolerance: what you see is what you don't get!  Nat. Immunol. 17:115-6.

2015

  • ​Lind, EF. Millar, DG. Dissanayake, D. Savage, JC. Grimshaw, NK. Kerr, WG. Ohashi, PS. (2015). MiR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1. J. Immunol. 195:4632-40.
  • Ng, D. Maître, B. Cummings, D. Lin, A. Ward, LA. Rahbar, R. Mossman, KL. Ohashi, PS. Gommerman, JL. (2015). A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology. J. Immunol. 195:4650-9.
  • Itsumi, M. Inoue, S. Elia, AJ. Murakami, K. Sasaki, M. Lind, EF. Brenner, D. Harris, IS. Chio, II. Afzal, S. Cairns, RA. Cescon, DW. Elford, AR. Ye, J. Lang, PA. Li, WY. Wakeham, A. Duncan, GS. Haight, J. You-Ten, A. Snow, B. Yamamoto, K. Ohashi, PS. Mak, TW. (2015). Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Cell Death Differ. 22:1837-45.
  • Bornancin, F. Renner, F. Touil, R. Sic, H. Kolb, Y. Touil-Allaoui, I. Rush, JS. Smith, PA. Bigaud, M. Junker-Walker, U. Burkhart, C. Dawson, J. Niwa, S. Katopodis, A. Nuesslein-Hildesheim, B. Weckbecker, G. Zenke, G. Kinzel, B. Traggiai, E. Brenner, D. Brüstle, A. St Paul, M. Zamurovic, N. McCoy, KD. Rolink, A. Régnier, CH. Mak, TW. Ohashi, PS. Patel, DD. Calzascia, T. (2015). Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation. J. Immunol. 194:3723-34.
  • Xu, HC. Huang, J. Khairnar, V. Duhan, V. Pandyra, AA. Grusdat, M. Shinde, P. McIlwain, DR. Maney, SK. Gommerman, J. Löhning, M. Ohashi, PS. Mak, TW. Pieper, K. Sic, H. Speletas, M. Eibel, H. Ware, CF. Tumanov, AV. Kruglov, AA. Nedospasov, SA. Häussinger, D. Recher, M. Lang, KS. Lang, PA. (2015). Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J. Virol. 89:4748-59.
  • Rahbar, R. Lin, A. Ghazarian, M. Yau, HL. Paramathas, S. Lang, PA. Schildknecht, A. Elford, AR. Garcia-Batres, C. Martin, B. Berman, HK. Leong, WL. McCready, DR. Reedijk, M. Done, SJ. Miller, N. Youngson, B. Suh, WK. Mak, TW. Ohashi, PS. (2015). B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. Cancer Immunol Res 3:184-95.

2014

  • Nguyen, LT. Ohashi, PS. (2014). Clinical blockade of PD1 and LAG3--potential mechanisms of action. Nat. Rev. Immunol. 15:45-56.
  • Lang, PA. Meryk, A. Pandyra, AA. Brenner, D. Brüstle, A. Xu, HC. Merches, K. Lang, F. Khairnar, V. Sharma, P. Funkner, P. Recher, M. Shaabani, N. Duncan, GS. Duhan, V. Homey, B. Ohashi, PS. Häussinger, D. Knolle, PA. Honke, N. Mak, TW. Lang, KS. (2014). Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death Differ. 22:164-73.
  • Parish, IA. Marshall, HD. Staron, MM. Lang, PA. Brüstle, A. Chen, JH. Cui, W. Tsui, YC. Perry, C. Laidlaw, BJ. Ohashi, PS. Weaver, CT. Kaech, SM. (2014). Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J. Clin. Invest. 124:3455-68.
  • Xu, HC. Grusdat, M. Pandyra, AA. Polz, R. Huang, J. Sharma, P. Deenen, R. Köhrer, K. Rahbar, R. Diefenbach, A. Gibbert, K. Löhning, M. Höcker, L. Waibler, Z. Häussinger, D. Mak, TW. Ohashi, PS. Lang, KS. Lang, PA. (2014). Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. Immunity 40:949-60.
  • Grusdat, M. McIlwain, DR. Xu, HC. Pozdeev, VI. Knievel, J. Crome, SQ. Robert-Tissot, C. Dress, RJ. Pandyra, AA. Speiser, DE. Lang, E. Maney, SK. Elford, AR. Hamilton, SR. Scheu, S. Pfeffer, K. Bode, J. Mittrücker, HW. Lohoff, M. Huber, M. Häussinger, D. Ohashi, PS. Mak, TW. Lang, KS. Lang, PA. (2014). IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death Differ. 21:1050-60.
  • Dissanayake, D. Murakami, K. Tran, MD. Elford, AR. Millar, DG. Ohashi, PS. (2014). Peptide-pulsed dendritic cells have superior ability to induce immune-mediated tissue destruction compared to peptide with adjuvant. PLoS ONE 9:e92380.
  • Lind, EF. Ohashi, PS. (2014). Mir-155, a central modulator of T-cell responses. Eur. J. Immunol. 44:11-5.
  • Brenner, D. Brüstle, A. Lin, GH. Lang, PA. Duncan, GS. Knobbe-Thomsen, CB. St Paul, M. Reardon, C. Tusche, MW. Snow, B. Hamilton, SR. Pfefferle, A. Gilani, SO. Ohashi, PS. Lang, KS. Mak, TW. (2014). Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 111:1060-5.

2013

  • Galon, J. Mlecnik, B. Bindea, G. Angell, HK. Berger, A. Lagorce, C. Lugli, A. Zlobec, I. Hartmann, A. Bifulco, C. Nagtegaal, ID. Palmqvist, R. Masucci, GV. Botti, G. Tatangelo, F. Delrio, P. Maio, M. Laghi, L. Grizzi, F. Asslaber, M. D'Arrigo, C. Vidal-Vanaclocha, F. Zavadova, E. Chouchane, L. Ohashi, PS. Hafezi-Bakhtiari, S. Wouters, BG. Roehrl, M. Nguyen, L. Kawakami, Y. Hazama, S. Okuno, K. Ogino, S. Gibbs, P. Waring, P. Sato, N. Torigoe, T. Itoh, K. Patel, PS. Shukla, SN. Wang, Y. Kopetz, S. Sinicrope, FA. Scripcariu, V. Ascierto, PA. Marincola, FM. Fox, BA. Pagès, F. (2013). Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J. Pathol. 232:199-209.
  • Robert-Tissot, C. Nguyen, LT. Ohashi, PS. Speiser, DE. (2013). Mobilizing and evaluating anticancer T cells: pitfalls and solutions. Expert Rev Vaccines 12:1325-40.
  • Johnson, DJ. Pao, LI. Dhanji, S. Murakami, K. Ohashi, PS. Neel, BG. (2013). Shp1 regulates T cell homeostasis by limiting IL-4 signals. J. Exp. Med. 210:1419-31.
  • Dervovic, DD. Liang, HC. Cannons, JL. Elford, AR. Mohtashami, M. Ohashi, PS. Schwartzberg, PL. Zúñiga-Pflücker, JC. (2013). Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch. J. Immunol. 191:1704-15.
  • Crome, SQ. Lang, PA. Lang, KS. Ohashi, PS. (2013). Natural killer cells regulate diverse T cell responses. Trends Immunol. 34:342-9.
  • Johnson, DJ. Ohashi, PS. (2013). Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance. Ann. N. Y. Acad. Sci. 1284:46-51.
  • Lang, PA. Xu, HC. Grusdat, M. McIlwain, DR. Pandyra, AA. Harris, IS. Shaabani, N. Honke, N. Maney, SK. Lang, E. Pozdeev, VI. Recher, M. Odermatt, B. Brenner, D. Häussinger, D. Ohashi, PS. Hengartner, H. Zinkernagel, RM. Mak, TW. Lang, KS. (2013). Reactive oxygen species delay control of lymphocytic choriomeningitis virus. Cell Death Differ. 20:649-58.
  • Lang, PA. Shaabani, N. Borkens, S. Honke, N. Scheu, S. Booth, S. Brenner, D. Meryk, A. Barthuber, C. Recher, M. Mak, TW. Ohashi, PS. Häussinger, D. Griffiths, GM. Thrasher, AJ. Bouma, G. Lang, KS. (2013). Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. J. Allergy Clin. Immunol. 131:815-24.
  • Lang, KS. Lang, PA. Meryk, A. Pandyra, AA. Boucher, LM. Pozdeev, VI. Tusche, MW. Göthert, JR. Haight, J. Wakeham, A. You-Ten, AJ. McIlwain, DR. Merches, K. Khairnar, V. Recher, M. Nolan, GP. Hitoshi, Y. Funkner, P. Navarini, AA. Verschoor, A. Shaabani, N. Honke, N. Penn, LZ. Ohashi, PS. Häussinger, D. Lee, KH. Mak, TW. (2013). Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc. Natl. Acad. Sci. U.S.A. 110:2593-8.
  • Galon, J. Pagès, F. Marincola, FM. Angell, HK. Thurin, M. Lugli, A. Zlobec, I. Berger, A. Bifulco, C. Botti, G. Tatangelo, F. Britten, CM. Kreiter, S. Chouchane, L. Delrio, P. Arndt, H. Asslaber, M. Maio, M. Masucci, GV. Mihm, M. Vidal-Vanaclocha, F. Allison, JP. Gnjatic, S. Hakansson, L. Huber, C. Singh-Jasuja, H. Ottensmeier, C. Zwierzina, H. Laghi, L. Grizzi, F. Ohashi, PS. Shaw, PA. Clarke, BA. Wouters, BG. Kawakami, Y. Hazama, S. Okuno, K. Wang, E. O'Donnell-Tormey, J. Lagorce, C. Pawelec, G. Nishimura, MI. Hawkins, R. Lapointe, R. Lundqvist, A. Khleif, SN. Ogino, S. Gibbs, P. Waring, P. Sato, N. Torigoe, T. Itoh, K. Patel, PS. Shukla, SN. Palmqvist, R. Nagtegaal, ID. Wang, Y. D'Arrigo, C. Kopetz, S. Sinicrope, FA. Trinchieri, G. Gajewski, TF. Ascierto, PA. Fox, BA. (2013). Cancer classification using the Immunoscore: a worldwide task force. J Transl Med. 10:205.
  • Lind, EF. Elford, AR. Ohashi, PS. (2013). Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges. J. Immunol. 190:1210-6.
  • Mulligan, AM. Raitman, I. Feeley, L. Pinnaduwage, D. Nguyen, LT. O'Malley, FP. Ohashi, PS. Andrulis, IL. (2013). Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. Clin. Cancer Res. 19:336-46.
  • Sukhai, MA. Prabha, S. Hurren, R. Rutledge, AC. Lee, AY. Sriskanthadevan, S. Sun, H. Wang, X. Skrtic, M. Seneviratne, A. Cusimano, M. Jhas, B. Gronda, M. MacLean, N. Cho, EE. Spagnuolo, PA. Sharmeen, S. Gebbia, M. Urbanus, M. Eppert, K. Dissanayake, D. Jonet, A. Dassonville-Klimpt, A. Li, X. Datti, A. Ohashi, PS. Wrana, J. Rogers, I. Sonnet, P. Ellis, WY. Corey, SJ. Eaves, C. Minden, MD. Wang, JC. Dick, JE. Nislow, C. Giaever, G. Schimmer, AD. (2013). Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors. J. Clin. Invest. 123:315-28.

2012

  • Lin, AE. Ebert, G. Ow, Y. Preston, SP. Toe, JG. Cooney, JP. Scott, HW. Sasaki, M. Saibil, SD. Dissanayake, D. Kim, RH. Wakeham, A. You-Ten, A. Shahinian, A. Duncan, G. Silvester, J. Ohashi, PS. Mak, TW. Pellegrini, M. (2012). ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat. Immunol. 14:27-33.
  • Brüstle, A. Brenner, D. Knobbe, CB. Lang, PA. Virtanen, C. Hershenfield, BM. Reardon, C. Lacher, SM. Ruland, J. Ohashi, PS. Mak, TW. (2012). The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J. Clin. Invest. 122:4698-709.
  • Sasaki, M. Knobbe, CB. Munger, JC. Lind, EF. Brenner, D. Brüstle, A. Harris, IS. Holmes, R. Wakeham, A. Haight, J. You-Ten, A. Li, WY. Schalm, S. Su, SM. Virtanen, C. Reifenberger, G. Ohashi, PS. Barber, DL. Figueroa, ME. Melnick, A. Zúñiga-Pflücker, JC. Mak, TW. (2012). IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 488:656-9.
  • Chen, G. Dimitriou, I. Milne, L. Lang, KS. Lang, PA. Fine, N. Ohashi, PS. Kubes, P. Rottapel, R. (2012). The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation. J. Immunol. 189:2138-50.
  • Rintoul, JL. Lemay, CG. Tai, LH. Stanford, MM. Falls, TJ. de Souza, CT. Bridle, BW. Daneshmand, M. Ohashi, PS. Wan, Y. Lichty, BD. Mercer, AA. Auer, RC. Atkins, HL. Bell, JC. (2012). ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic. Mol. Ther. 20:1148-57.
  • Fox, BA. Schendel, DJ. Butterfield, LH. Aamdal, S. Allison, JP. Ascierto, PA. Atkins, MB. Bartunkova, J. Bergmann, L. Berinstein, N. Bonorino, CC. Borden, E. Bramson, JL. Britten, CM. Cao, X. Carson, WE. Chang, AE. Characiejus, D. Choudhury, AR. Coukos, G. de Gruijl, T. Dillman, RO. Dolstra, H. Dranoff, G. Durrant, LG. Finke, JH. Galon, J. Gollob, JA. Gouttefangeas, C. Grizzi, F. Guida, M. Håkansson, L. Hege, K. Herberman, RB. Hodi, FS. Hoos, A. Huber, C. Hwu, P. Imai, K. Jaffee, EM. Janetzki, S. June, CH. Kalinski, P. Kaufman, HL. Kawakami, K. Kawakami, Y. Keilholtz, U. Khleif, SN. Kiessling, R. Kotlan, B. Kroemer, G. Lapointe, R. Levitsky, HI. Lotze, MT. Maccalli, C. Maio, M. Marschner, JP. Mastrangelo, MJ. Masucci, G. Melero, I. Melief, C. Murphy, WJ. Nelson, B. Nicolini, A. Nishimura, MI. Odunsi, K. Ohashi, PS. O'Donnell-Tormey, J. Old, LJ. Ottensmeier, C. Papamichail, M. Parmiani, G. Pawelec, G. Proietti, E. Qin, S. Rees, R. Ribas, A. Ridolfi, R. Ritter, G. Rivoltini, L. Romero, PJ. Salem, ML. Scheper, RJ. Seliger, B. Sharma, P. Shiku, H. Singh-Jasuja, H. Song, W. Straten, PT. Tahara, H. Tian, Z. van Der Burg, SH. von Hoegen, P. Wang, E. Welters, MJ. Winter, H. Withington, T. Wolchok, JD. Xiao, W. Zitvogel, L. Zwierzina, H. Marincola, FM. Gajewski, TF. Wigginton, JM. Disis, ML. (2012). Defining the critical hurdles in cancer immunotherapy. J Transl Med. 9:214.
  • Arpaia, E. Blaser, H. Quintela-Fandino, M. Duncan, G. Leong, HS. Ablack, A. Nambiar, SC. Lind, EF. Silvester, J. Fleming, CK. Rufini, A. Tusche, MW. Brüstle, A. Ohashi, PS. Lewis, JD. Mak, TW. (2012). The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene 31:884-96.
  • Lang, PA. Lang, KS. Xu, HC. Grusdat, M. Parish, IA. Recher, M. Elford, AR. Dhanji, S. Shaabani, N. Tran, CW. Dissanayake, D. Rahbar, R. Ghazarian, M. Brüstle, A. Fine, J. Chen, P. Weaver, CT. Klose, C. Diefenbach, A. Häussinger, D. Carlyle, JR. Kaech, SM. Mak, TW. Ohashi, PS. (2012). Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc. Natl. Acad. Sci. U.S.A. 109:1210-5.
  • Wang, C. McPherson, AJ. Jones, RB. Kawamura, KS. Lin, GH. Lang, PA. Ambagala, T. Pellegrini, M. Calzascia, T. Aidarus, N. Elford, AR. Yue, FY. Kremmer, E. Kovacs, CM. Benko, E. Tremblay, C. Routy, JP. Bernard, NF. Ostrowski, MA. Ohashi, PS. Watts, TH. (2012). Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. J. Exp. Med. 209:77-91.
  • Hao, Z. Duncan, GS. Su, YW. Li, WY. Silvester, J. Hong, C. You, H. Brenner, D. Gorrini, C. Haight, J. Wakeham, A. You-Ten, A. McCracken, S. Elia, A. Li, Q. Detmar, J. Jurisicova, A. Hobeika, E. Reth, M. Sheng, Y. Lang, PA. Ohashi, PS. Zhong, Q. Wang, X. Mak, TW. (2012). The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J. Exp. Med. 209:173-86.
  • McIlwain, DR. Lang, PA. Maretzky, T. Hamada, K. Ohishi, K. Maney, SK. Berger, T. Murthy, A. Duncan, G. Xu, HC. Lang, KS. Häussinger, D. Wakeham, A. Itie-Youten, A. Khokha, R. Ohashi, PS. Blobel, CP. Mak, TW. (2012). iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science 335:229-32.
  • Kuchroo, VK. Ohashi, PS. Sartor, RB. Vinuesa, CG. (2012). Dysregulation of immune homeostasis in autoimmune diseases. Nat. Med. 18:42-7.

2011

  • Dissanayake, D. Hall, H. Berg-Brown, N. Elford, AR. Hamilton, SR. Murakami, K. Deluca, LS. Gommerman, JL. Ohashi, PS. (2011). Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells. Nat. Med. 17:1663-7.
  • Lin, AC. Dissanayake, D. Dhanji, S. Elford, AR. Ohashi, PS. (2011). Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. PLoS ONE 6:e23940.
  • Ramanathan, S. Dubois, S. Chen, XL. Leblanc, C. Ohashi, PS. Ilangumaran, S. (2011). Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes. J. Immunol. 186:5131-41.
  • Dissanayake, D. Gronski, MA. Lin, A. Elford, AR. Ohashi, PS. (2011). Immunological perspective of self versus tumor antigens: insights from the RIP-gp model. Immunol. Rev. 241:164-79.
  • Pellegrini, M. Calzascia, T. Toe, JG. Preston, SP. Lin, AE. Elford, AR. Shahinian, A. Lang, PA. Lang, KS. Morre, M. Assouline, B. Lahl, K. Sparwasser, T. Tedder, TF. Paik, JH. DePinho, RA. Basta, S. Ohashi, PS. Mak, TW. (2011). IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144:601-13.
  • Liontos, LM. Dissanayake, D. Ohashi, PS. Weiss, A. Dragone, LL. McGlade, CJ. (2011). The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J. Immunol. 186:1923-33.

2010

  • Murakami, K. Liadis, N. Sarmiento, J. Elford, AR. Woo, M. Nguyen, LT. Mak, TW. Ohashi, PS. (2010). Caspase 3 is not essential for the induction of anergy or multiple pathways of CD8+ T-cell death. Eur. J. Immunol. 40:3372-7.
  • Nguyen, LT. Yen, PH. Nie, J. Liadis, N. Ghazarian, D. Al-Habeeb, A. Easson, A. Leong, W. Lipa, J. McCready, D. Reedijk, M. Hogg, D. Joshua, AM. Quirt, I. Messner, H. Shaw, P. Crump, M. Sharon, E. Ohashi, PS. (2010). Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs). PLoS ONE 5:e13940.
  • Lang, PA. Merkler, D. Funkner, P. Shaabani, N. Meryk, A. Krings, C. Barthuber, C. Recher, M. Brück, W. Häussinger, D. Ohashi, PS. Lang, KS. (2010). Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur. J. Immunol. 40:2401-8.
  • Pellegrini, M. Mak, TW. Ohashi, PS. (2010). Fighting cancers from within: augmenting tumor immunity with cytokine therapy. Trends Pharmacol. Sci. 31:356-63.
  • Lang, PA. Recher, M. Honke, N. Scheu, S. Borkens, S. Gailus, N. Krings, C. Meryk, A. Kulawik, A. Cervantes-Barragan, L. Van Rooijen, N. Kalinke, U. Ludewig, B. Hengartner, H. Harris, N. Häussinger, D. Ohashi, PS. Zinkernagel, RM. Lang, KS. (2010). Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 52:25-32.
  • Doulatov, S. Notta, F. Eppert, K. Nguyen, LT. Ohashi, PS. Dick, JE. (2010). Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat. Immunol. 11:585-93.
  • Ramanathan, S. Dubois, S. Gagnon, J. Leblanc, C. Mariathasan, S. Ferbeyre, G. Rottapel, R. Ohashi, PS. Ilangumaran, S. (2010). Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens. J. Immunol. 185:357-66.
  • Lin, GH. Liu, Y. Ambagala, T. Kwon, BS. Ohashi, PS. Watts, TH. (2010). Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice. PLoS ONE 5:e11003.
  • Deenick, EK. Po, L. Chapatte, L. Murakami, K. Lu, YC. Elford, AR. Saibil, SD. Ruland, J. Gerondakis, S. Mak, TW. Ohashi, PS. (2010). c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance. Eur. J. Immunol. 40:867-77.
  • Deenick, EK. Elford, AR. Pellegrini, M. Hall, H. Mak, TW. Ohashi, PS. (2010). c-Rel but not NF-kappaB1 is important for T regulatory cell development. Eur. J. Immunol. 40:677-81.
  • Quintela-Fandino, M. Arpaia, E. Brenner, D. Goh, T. Yeung, FA. Blaser, H. Alexandrova, R. Lind, EF. Tusche, MW. Wakeham, A. Ohashi, PS. Mak, TW. (2010). HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc. Natl. Acad. Sci. U.S.A. 107:2622-7.
  • Lin, A. Schildknecht, A. Nguyen, LT. Ohashi, PS. (2010). Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth. Immunol. Lett. 127:77-84.

2009

  • Kamizono, S. Duncan, GS. Seidel, MG. Morimoto, A. Hamada, K. Grosveld, G. Akashi, K. Lind, EF. Haight, JP. Ohashi, PS. Look, AT. Mak, TW. (2009). Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J. Exp. Med. 206:2977-86.
  • Alam, MU. Harken, JA. Knorn, AM. Elford, AR. Wigmore, K. Ohashi, PS. Millar, DG. (2009). Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage. J. Immunol. 183:5728-37.
  • Kim, IR. Murakami, K. Chen, NJ. Saibil, SD. Matysiak-Zablocki, E. Elford, AR. Bonnard, M. Benchimol, S. Jurisicova, A. Yeh, WC. Ohashi, PS. (2009). DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis 14:1039-49.
  • Schildknecht, A. Probst, HC. McCoy, KD. Miescher, I. Brenner, C. Leone, DP. Suter, U. Ohashi, PS. van den Broek, M. (2009). Antigens expressed by myelinating glia cells induce peripheral cross-tolerance of endogenous CD8+ T cells. Eur. J. Immunol. 39:1505-15.
  • Lu, YC. Kim, I. Lye, E. Shen, F. Suzuki, N. Suzuki, S. Gerondakis, S. Akira, S. Gaffen, SL. Yeh, WC. Ohashi, PS. (2009). Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J. Immunol. 182:7212-21.
  • Pellegrini, M. Calzascia, T. Elford, AR. Shahinian, A. Lin, AE. Dissanayake, D. Dhanji, S. Nguyen, LT. Gronski, MA. Morre, M. Assouline, B. Lahl, K. Sparwasser, T. Ohashi, PS. Mak, TW. (2009). Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nature Medicine 15:528-36.
  • Lang, PA. Cervantes-Barragan, L. Verschoor, A. Navarini, AA. Recher, M. Pellegrini, M. Flatz, L. Bergthaler, A. Honda, K. Ludewig, B. Ohashi, PS. Lang, KS. (2009). Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 113:1045-52.s

2008

  • Lang, PA. Contaldo, C. Georgiev, P. El-Badry, AM. Recher, M. Kurrer, M. Cervantes-Barragan, L. Ludewig, B. Calzascia, T. Bolinger, B. Merkler, D. Odermatt, B. Bader, M. Graf, R. Clavien, PA. Hegazy, AN. Löhning, M. Harris, NL. Ohashi, PS. Hengartner, H. Zinkernagel, RM. Lang, KS. (2008). Aggravation of viral hepatitis by platelet-derived serotonin. Nat. Med. 14:756-61.
  • Lu, YC. Yeh, WC. Ohashi, PS. (2008). LPS/TLR4 signal transduction pathway. Cytokine 42:145-51.
  • Tsui, H. Chan, Y. Tang, L. Winer, S. Cheung, RK. Paltser, G. Selvanantham, T. Elford, AR. Ellis, JR. Becker, DJ. Ohashi, PS. Dosch, HM. (2008). Targeting of pancreatic glia in type 1 diabetes. Diabetes 57:918-28.
  • Calzascia, T. Pellegrini, M. Lin, A. Garza, KM. Elford, AR. Shahinian, A. Ohashi, PS. Mak, TW. (2008). CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc. Natl. Acad. Sci. U.S.A. 105:2999-3004.
  • Lye, E. Dhanji, S. Calzascia, T. Elford, AR. Ohashi, PS. (2008). IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. Eur. J. Immunol. 38:870-6.
  • Dufner, A. Duncan, GS. Wakeham, A. Elford, AR. Hall, HT. Ohashi, PS. Mak, TW. (2008). CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Mol. Cell. Biol. 28:1541-52.
  • Marshak-Rothstein, A. Ohashi, PS. (2008). Intricate connections between innate and adaptive autoimmunity. Curr. Opin. Immunol. 19:603-5.

2007

  • Hall, HT. Wilhelm, MT. Saibil, SD. Mak, TW. Flavell, RA. Ohashi, PS. (2007). RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses. Eur. J. Immunol. 38:64-72.
  • Saibil, SD. Deenick, EK. Ohashi, PS. (2007). The sound of silence: modulating anergy in T lymphocytes. Curr. Opin. Immunol. 19:658-64.
  • Calzascia, T. Pellegrini, M. Hall, H. Sabbagh, L. Ono, N. Elford, AR. Mak, TW. Ohashi, PS. (2007). TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice. J. Clin. Invest. 117:3833-45.
  • Ford, MS. Chen, W. Wong, S. Li, C. Vanama, R. Elford, AR. Asa, SL. Ohashi, PS. Zhang, L. (2007). Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development.Eur. J. Immunol. 37:2234-41.
  • Lemmers, B. Salmena, L. Bidère, N. Su, H. Matysiak-Zablocki, E. Murakami, K. Ohashi, PS. Jurisicova, A. Lenardo, M. Hakem, R. Hakem, A. (2007). Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. J. Biol. Chem. 282:7416-23.
  • Saibil, SD. Jones, RG. Deenick, EK. Liadis, N. Elford, AR. Vainberg, MG. Baerg, H. Woodgett, JR. Gerondakis, S. Ohashi, PS. (2007). CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. J. Immunol. 178:2932-9.

2006

  • ​Ohashi, PS. Yeh, WC. (2006). Supressing the supressors. Nat. Med. 12:1000-2.
  • Suh, WK. Wang, S. Duncan, GS. Miyazaki, Y. Cates, E. Walker, T. Gajewska, BU. Deenick, E. Dawicki, W. Okada, H. Wakeham, A. Itie, A. Watts, TH. Ohashi, PS. Jordana, M. Yoshida, H. Mak, TW. (2006). Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol. Cell. Biol. 26:6403-11.
  • Suzuki, N. Suzuki, S. Millar, DG. Unno, M. Hara, H. Calzascia, T. Yamasaki, S. Yokosuka, T. Chen, NJ. Elford, AR. Suzuki, J. Takeuchi, A. Mirtsos, C. Bouchard, D. Ohashi, PS. Yeh, WC. Saito, T. (2006). A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311:1927-32.

2005

  • ​Jones, RG. Saibil, SD. Pun, JM. Elford, AR. Bonnard, M. Pellegrini, M. Arya, S. Parsons, ME. Krawczyk, CM. Gerondakis, S. Yeh, WC. Woodgett, JR. Boothby, MR. Ohashi, PS. (2005). NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. J. Immunol. 175:3790-9.
  • Ohashi, PS. Woodgett, JR. (2005). Modulating autoimmunity: pick your PI3 kinase. Nat. Med. 11:924-5.
  • Woodgett, JR. Ohashi, PS. (2005). GSK3: an in-Toll-erant protein kinase? Nat. Immunol. 6:751-2.
  • Cheung, H. Chen, NJ. Cao, Z. Ono, N. Ohashi, PS. Yeh, WC. (2005). Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174:5351-7.
  • Liadis, N. Murakami, K. Eweida, M. Elford, AR. Sheu, L. Gaisano, HY. Hakem, R. Ohashi, PS. Woo, M. (2005). Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol. Cell. Biol. 25:3620-9.
  • Kwon, H. Jun, HS. Yang, Y. Mora, C. Mariathasan, S. Ohashi, PS. Flavell, RA. Yoon, JW. (2005). Development of autoreactive diabetogenic T cells in the thymus of NOD mice. J. Autoimmun. 24:11-23.
  • Krawczyk, CM. Jones, RG. Atfield, A. Bachmaier, K. Arya, S. Odermatt, B. Ohashi, PS. Penninger, JM. (2005). Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J. Immunol. 174:1472-8.

2004

  • Gronski, MA. Boulter, JM. Moskophidis, D. Nguyen, LT. Holmberg, K. Elford, AR. Deenick, EK. Kim, HO. Penninger, JM. Odermatt, B. Gallimore, A. Gascoigne, NR. Ohashi, PS. (2004). TCR affinity and negative regulation limit autoimmunity. Nat. Med. 10:1234-9.
  • Suh, WK. Tafuri, A. Berg-Brown, NN. Shahinian, A. Plyte, S. Duncan, GS. Okada, H. Wakeham, A. Odermatt, B. Ohashi, PS. Mak, TW. (2004). The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28. J. Immunol. 172:5917-23.
  • Schmitt, TM. de Pooter, RF. Gronski, MA. Cho, SK. Ohashi, PS. Zúñiga-Pflücker, JC. (2004). Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat. Immunol. 5:410-7.
  • Berg-Brown, NN. Gronski, MA. Jones, RG. Elford, AR. Deenick, EK. Odermatt, B. Littman, DR. Ohashi, PS. (2004). PKCtheta signals activation versus tolerance in vivo. J. Exp. Med. 199:743-52.

2003

  • ​Millar, DG. Garza, KM. Odermatt, B. Elford, AR. Ono, N. Li, Z. Ohashi, PS. (2003). Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo. Nat. Med. 9:1469-76.
  • Ohashi, PS. (2003). Negative selection and autoimmunity. Curr. Opin. Immunol. 15:668-76.
  • Sarvetnick, N. Ohashi, PS. (2003). Autoimmunity. Curr. Opin. Immunol. 15:647-50.
  • Suh, WK. Gajewska, BU. Okada, H. Gronski, MA. Bertram, EM. Dawicki, W. Duncan, GS. Bukczynski, J. Plyte, S. Elia, A. Wakeham, A. Itie, A. Chung, S. Da Costa, J. Arya, S. Horan, T. Campbell, P. Gaida, K. Ohashi, PS. Watts, TH. Yoshinaga, SK. Bray, MR. Jordana, M. Mak, TW. (2003). The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4:899-906.
  • Holmberg, K. Mariathasan, S. Ohteki, T. Ohashi, PS. Gascoigne, NR. (2003). TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J. Immunol. 171:2427-34.
  • Mak, TW. Shahinian, A. Yoshinaga, SK. Wakeham, A. Boucher, LM. Pintilie, M. Duncan, G. Gajewska, BU. Gronski, M. Eriksson, U. Odermatt, B. Ho, A. Bouchard, D. Whorisky, JS. Jordana, M. Ohashi, PS. Pawson, T. Bladt, F. Tafuri, A. (2003). Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol. 4:765-72.
  • Pitcher, LA. Ohashi, PS. van Oers, NS. (2003). T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits. J. Immunol. 171:845-52.
  • Suzuki, N. Chen, NJ. Millar, DG. Suzuki, S. Horacek, T. Hara, H. Bouchard, D. Nakanishi, K. Penninger, JM. Ohashi, PS. Yeh, WC. (2003). IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J. Immunol. 170:4031-5.
  • Salmena, L. Lemmers, B. Hakem, A. Matysiak-Zablocki, E. Murakami, K. Au, PY. Berry, DM. Tamblyn, L. Shehabeldin, A. Migon, E. Wakeham, A. Bouchard, D. Yeh, WC. McGlade, JC. Ohashi, PS. Hakem, R. (2003). Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev. 17:883-95.
  • Saibil, SD. Ohteki, T. White, FM. Luscher, M. Zakarian, A. Elford, A. Shabanowitz, J. Nishina, H. Hugo, P. Penninger, J. Barber, B. Hunt, DF. Ohashi, PS. (2003). Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur. J. Immunol. 33:685-96.

2002

  • Ohashi, PS. (2002). Immunology. Exposing thy self. Science 298:1348-9.
  • Bertram, EM. Tafuri, A. Shahinian, A. Chan, VS. Hunziker, L. Recher, M. Ohashi, PS. Mak, TW. Watts, TH. (2002). Role of ICOS versus CD28 in antiviral immunity. Eur. J. Immunol. 32:3376-85.
  • Ohashi, PS. DeFranco, AL. (2002). Making and breaking tolerance. Curr. Opin. Immunol. 14:744-59.
  • Jones, RG. Elford, AR. Parsons, MJ. Wu, L. Krawczyk, CM. Yeh, WC. Hakem, R. Rottapel, R. Woodgett, JR. Ohashi, PS. (2002). CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J. Exp. Med. 196:335-48.
  • Ford, MS. Young, KJ. Zhang, Z. Ohashi, PS. Zhang, L. (2002). The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J. Exp. Med. 196:261-7.
  • Ohashi, PS. (2002). T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat. Rev. Immunol. 2:427-38.
  • Chan, VS. Wong, C. Ohashi, PS. (2002). Calcineurin Aalpha plays an exclusive role in TCR signaling in mature but not in immature T cells. Eur. J. Immunol. 32:1223-9.
  • Kawamura, KS. Su, RC. Nguyen, LT. Elford, AR. Ohashi, PS. Gariépy, J. (2002). In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles. J. Immunol. 168:5709-15.
  • Nguyen, LT. Bachmann, MF. Ohashi, PS. (2002). Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance, and autoimmunity. Curr. Top. Microbiol. Immunol. 263:119-43.
  • Suzuki, N. Suzuki, S. Duncan, GS. Millar, DG. Wada, T. Mirtsos, C. Takada, H. Wakeham, A. Itie, A. Li, S. Penninger, JM. Wesche, H. Ohashi, PS. Mak, TW. Yeh, WC. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416:750-6.
  • Krawczyk, C. Oliveira-dos-Santos, A. Sasaki, T. Griffiths, E. Ohashi, PS. Snapper, S. Alt, F. Penninger, JM. (2002). Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16:331-43.
  • Mak, TW. Penninger, JM. Ohashi, PS. (2002). Knockout mice: a paradigm shift in modern immunology. Nat. Rev. Immunol. 1:11-9.
  • Nguyen, LT. Elford, AR. Murakami, K. Garza, KM. Schoenberger, SP. Odermatt, B. Speiser, DE. Ohashi, PS. (2002). Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J. Exp. Med. 195:423-35.
  • Garza, KM. McKall-Faienza, KJ. Otheki, T. Zakarian, A. Odermatt, B. Ohashi, PS. (2002). Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur. J. Immunol. 32:885-94.

2001

  • ​Mariathasan, S. Zakarian, A. Bouchard, D. Michie, AM. Zúñiga-Pflücker, JC. Ohashi, PS. (2001). Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. J. Immunol. 167:4966-73.
  • Griffiths, EK. Krawczyk, C. Kong, YY. Raab, M. Hyduk, SJ. Bouchard, D. Chan, VS. Kozieradzki, I. Oliveira-Dos-Santos, AJ. Wakeham, A. Ohashi, PS. Cybulsky, MI. Rudd, CE. Penninger, JM. (2001). Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 293:2260-3.
  • Garza, KM. Nguyen, LT. Jones, RG. Ohashi, PS. (2001). Factors contributing to autoimmune disease. Adv. Exp. Med. Biol. 490:7-19.
  • Parsons, MJ. Jones, RG. Tsao, MS. Odermatt, B. Ohashi, PS. Woodgett, JR. (2001). Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. J. Immunol. 167:42-8.
  • Suzuki, A. Yamaguchi, MT. Ohteki, T. Sasaki, T. Kaisho, T. Kimura, Y. Yoshida, R. Wakeham, A. Higuchi, T. Fukumoto, M. Tsubata, T. Ohashi, PS. Koyasu, S. Penninger, JM. Nakano, T. Mak, TW. (2001). T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14:523-34.
  • Tafuri, A. Shahinian, A. Bladt, F. Yoshinaga, SK. Jordana, M. Wakeham, A. Boucher, LM. Bouchard, D. Chan, VS. Duncan, G. Odermatt, B. Ho, A. Itie, A. Horan, T. Whoriskey, JS. Pawson, T. Penninger, JM. Ohashi, PS. Mak, TW. (2001). ICOS is essential for effective T-helper-cell responses. Nature 409:105-9.
  • Garza, KM. Chan, VS. Ohashi, PS. (2001). T cell tolerance and autoimmunity. Rev Immunogenet 2:2-17.
  • Okkenhaug, K. Wu, L. Garza, KM. La Rose, J. Khoo, W. Odermatt, B. Mak, TW. Ohashi, PS. Rottapel, R. (2001). A point mutation in CD28 distinguishes proliferative signals from survival signals.Nat. Immunol. 2:325-32.
  • Ruland, J. Duncan, GS. Elia, A. del Barco Barrantes, I. Nguyen, L. Plyte, S. Millar, DG. Bouchard, D. Wakeham, A. Ohashi, PS. Mak, TW. (2001). Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104:33-42.